Article
The central core region of yeast ribosomal protein L11 is important for subunit joining and translational fidelity.
Molecular genetics and genomics : MGG - 1 Jun 2011
Rhodin Michael H J, Rakauskaitė Rasa, Dinman Jonathan D
Abstract excerpt
Yeast ribosomal protein L11 is positioned at the intersubunit cleft of the large subunit central protuberance, forming an intersubunit bridge with the small subunit protein S18. Mutants were engineered in the central core region of L11 which interacts with Helix 84 of the 25S rRNA. Numerous mutants in this region conferred 60S subunit biogenesis defects. Specifically, many mutations of F96 and the A66D mutant...
Topics
- Binding Sites
- Mutation
- Nucleic Acid Conformation
- Protein Biosynthesis
- Protein Engineering
- RNA, Ribosomal
- Ribosomal Proteins
- Ribosomes
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins