Article
Detection of a key tertiary interaction in the highly conserved GTPase center of large subunit ribosomal RNA.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1991
Ryan P C, Draper D E
Abstract excerpt
Searches of ribosomal RNA sequences for compensatory base changes preserving Watson-Crick base pairing have led to detailed models of the conserved secondary structures of these RNAs. In principle, tertiary interactions can also be detected by searches for phylogenetically covariant bases. Within a highly conserved region of the large subunit ribosomal RNA termed the "GTPase center," the bases...
Topics
- Base Sequence
- Binding Sites
- Escherichia coli
- GTP Phosphohydrolases
- Genetic Variation
- Models, Structural
- Molecular Sequence Data
- Nucleic Acid Conformation
- Phylogeny
- RNA, Ribosomal, 23S
- Thiostrepton