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Article

A flexible loop in yeast ribosomal protein L11 coordinates P-site tRNA binding.

Nucleic acids research - 1 Dec 2010

Rhodin Michael H J, Dinman Jonathan D

Abstract excerpt

High-resolution structures reveal that yeast ribosomal protein L11 and its bacterial/archael homologs called L5 contain a highly conserved, basically charged internal loop that interacts with the peptidyl-transfer RNA (tRNA) T-loop. We call this the L11 'P-site loop'. Chemical protection of wild-type ribosome shows that that the P-site loop is inherently flexible, i.e. it is extended into the ribosomal P-site...

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Identifiers

PMID: 20705654
DOI: 10.1093/nar/gkq711
PMCID: PMC3001080

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