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Article

Control of neural crest induction by MarvelD3-mediated attenuation of JNK signalling.

Scientific reports - 19 Jan 2018

Vacca Barbara, Sanchez-Heras Elena, Steed Emily, Busson Sophie L, Balda Maria S, Ohnuma Shin-Ichi, Sasai Noriaki, Mayor Roberto, Matter Karl

Abstract excerpt

Tight junctions are required for the formation of tissue barriers and function as suppressors of signalling mechanisms that control gene expression and cell behaviour; however, little is known about the physiological and developmental importance of such signalling functions. Here, we demonstrate that depletion of MarvelD3, a transmembrane protein of tight junctions, disrupts neural crest formation and,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29352236
DOI: 10.1038/s41598-018-19579-5
PMCID: PMC5775312

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