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Article

Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan.

Endocrine journal - 1 Jan 2009

Nishihara Eijun, Amino Nobuyuki, Maekawa Kayoko, Yoshida Hiroshi, Ito Mitsuru, Kubota Sumihisa, Fukata Shuji, Miyauchi Akira

Abstract excerpt

Somatic mutations of the thyrotropin receptor (TSHR) gene and the gene encoding the alpha subunit of the stimulatory GTP-binding protein (Gsalpha) are the main cause for autonomously functioning thyroid nodules (AFTN) in iodine-deficient regions of the world. In iodine-sufficient regions, including Japan, the genetic relevance of AFTN is unclear. In a series of 45 Japanese subjects with AFTN, exons 9 and 10 of...

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Source

Identifiers

PMID: 19550078
DOI: 10.1507/endocrj.k09e-073

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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