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Article

Two rare TSH receptor amino acid substitutions in toxic thyroid adenomas.

Endocrine journal - 1 Jan 2012

Nanba Kazutaka, Usui Takeshi, Minamiguchi Sachiko, Mori Yusuke, Watanabe Yoshiki, Honda Keigo, Asato Ryo, Nakao Kanako, Kawashima Sachiko-Tsukamoto, Yuno Akiko, Tamanaha Tamiko, Tagami Tetsuya, Naruse Mitsuhide, Akiyama Yuichi, Shimatsu Akira

Abstract excerpt

Toxic adenoma and toxic multinodular goiter (TMNG) are common causes of hyperthyroidism in iodine-deficient regions, but they are relatively rare in iodine-sufficient regions, including Japan. Constitutive activating mutations of the thyroid stimulating hormone receptor (TSHR) gene and adenylate cyclase-stimulating G α protein (GNAS) gene are frequent in these thyrotoxic disorders. Here we report two cases of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22001338
DOI: 10.1507/endocrj.ej11-0202

Genes

TSHR
GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two rare TSH receptor amino acid substitutions in toxic thyroid adenomas.PMID 22001338Read ↗

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