[Mutations in the thyrotropin receptor gene in the pathogenesis of toxic thyroid adenomas, toxic goiter nodules and autosomal dominant hyperthyroidism].

Abstract excerpt

In iodine deficiency regions such as Germany, more than 50% of toxic thyroid adenomas and some toxic goiter nodules harbor activating mutations in the TSH receptor or Gs-alpha gene. These mutations cause cellular hyperfunction and hyperthyroidism but are not sufficient to generate thyroid adenomas and nodules. In the pathogenesis of these tumors, other primary and secondary molecular mechanism are operative,...

Topics

• Adenoma
• Animals
• Genes, Dominant
• Goiter, Nodular
• Humans
• Hyperthyroidism
• Mutation
• Receptors, Thyrotropin
• Thyroid Neoplasms