Article
Somatic mutations in the thyrotropin receptor gene and not in the Gs alpha protein gene in 31 toxic thyroid nodules.
The Journal of clinical endocrinology and metabolism - 1 Nov 1997
Führer D, Holzapfel H P, Wonerow P, Scherbaum W A, Paschke R
Abstract excerpt
Studies on frequency and distribution pattern of TSH receptor (TSHR) and Gs alpha protein (gsp) mutations in toxic thyroid nodules (TTNs) reported conflicting results, most likely also related to the different screening methods applied and the investigation of only part of exon 10 of the TSHR. Th...
Topics
- Amino Acid Sequence
- Cyclic AMP
- Exons
- GTP-Binding Protein alpha Subunits, Gs
- Gene Deletion
- Humans
- Molecular Sequence Data
- Mutation
- Phenylalanine
- Polymerase Chain Reaction
- Protein Conformation
- Receptors, Thyrotropin
- Thyroid Nodule
- Valine