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Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells

22 Apr 2003

Abstract excerpt

Human embryonic stem cells (hESCs) randomly differentiate into multiple cell types during embryoid body (EB) development. To date, characterization of specific factors capable of influencing hematopoietic cell fate from hESCs remains elusive. Here, we report that the treatment of hESCs during EB development with a combination of cytokines and bone morphogenetic protein-4 (BMP-4), a ventral mesoderm inducer,...

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Identifiers

PMID: 12702499
DOI: 10.1182/blood-2003-03-0832

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