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Article

Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease.

Scandinavian journal of gastroenterology - 1 Oct 2006

Oostenbrug Liekele E, Dijkstra Gerard, Nolte Ilja M, van Dullemen Hendrik M, Oosterom Elvira, Faber Klaas N, de Jong Dirk J, van der Linde Klaas, te Meerman Gerard J, van der Steege Gerrit, Kleibeuker Jan H, Jansen Peter L M

Abstract excerpt

OBJECTIVE: The multidrug resistance (MDR1) gene encodes for P-glycoprotein, a drug efflux pump. Mice deficient for the MDR1a gene spontaneously develop colitis. In humans, a polymorphism in exon 26 (C3435T) is associated with reduced expression levels and function of MDR1. Currently there are controversial data on the association between MDR1 and inflammatory bowel disease (IBD). The purpose of this study was to...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Multiple

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Share to Inflammatory Bowel Diseases

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Source

Identifiers

PMID: 16990202
DOI: 10.1080/00365520600575746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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