Article
Multidrug resistance 1 gene polymorphisms are not associated with inflammatory bowel disease and response to therapy in Italian patients.
Alimentary pharmacology & therapeutics - 1 Dec 2005
Palmieri O, Latiano A, Valvano R, D'Incà R, Vecchi M, Sturniolo G C, Saibeni S, Bossa F, Latiano T, Devoto M, Andriulli A, Annese V
Abstract excerpt
BACKGROUND: Host genetic factors may be important in determining not only disease susceptibility, but also disease behaviour and response to therapy in inflammatory bowel disease. Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's...
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