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Article

Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification.

Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2004

Hough Tertius A, Bogani Debora, Cheeseman Michael T, Favor Jack, Nesbit M Andrew, Thakker Rajesh V, Lyon Mary F

Abstract excerpt

The extracellular calcium-sensing receptor (CaSR) plays a pivotal role in the regulation of extracellular calcium such that abnormalities, which result in a loss or gain of function, lead to hypercalcemia or hypocalcemia, respectively, in patients. Mice carrying CaSR knockout alleles develop hypercalcemia that mimics the disorders observed in humans. To date, there is no mouse model for an activating CaSR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15347804
DOI: 10.1073/pnas.0405516101
PMCID: PMC518795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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