Article
Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2008
Davey Rachel A, Turner Andrew G, McManus Julie F, Chiu W S Maria, Tjahyono Francisca, Moore Alison J, Atkins Gerald J, Anderson Paul H, Ma Cathy, Glatt Vaida, MacLean Helen E, Vincent Cristina, Bouxsein Mary, Morris Howard A, Findlay David M, Zajac Jeffrey D
Abstract excerpt
It is well established that calcitonin is a potent inhibitor of bone resorption; however, a physiological role for calcitonin acting through its cognate receptor, the calcitonin receptor (CTR), has not been identified. Data from previous genetically modified animal models have recognized a possible role for calcitonin and the CTR in controlling bone formation; however, interpretation of these data are...
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