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Article

Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.

JCI insight - 9 Feb 2017

Gorvin Caroline M, Hannan Fadil M, Howles Sarah A, Babinsky Valerie N, Piret Sian E, Rogers Angela, Freidin Andrew J, Stewart Michelle, Paudyal Anju, Hough Tertius A, Nesbit M Andrew, Wells Sara, Vincent Tonia L, Brown Stephen Dm, Cox Roger D, Thakker Rajesh V

Abstract excerpt

Heterozygous germline gain-of-function mutations of G-protein subunit α11 (Gα11), a signaling partner for the calcium-sensing receptor (CaSR), result in autosomal dominant hypocalcemia type 2 (ADH2). ADH2 may cause symptomatic hypocalcemia with low circulating parathyroid hormone (PTH) concentrations. Effective therapies for ADH2 are currently not available, and a mouse model for ADH2 would help in assessment of...

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Source

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Identifiers

PMID: 28194447
DOI: 10.1172/jci.insight.91103
PMCID: PMC5291742

Genes

PTH
NPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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