Article
Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.
Cell - 8 Mar 1991
Flanagan J G, Chan D C, Leder P
Abstract excerpt
The ligand (KL) for the c-kit receptor is a growth factor encoded at the mouse steel (Sl) locus. KL exists in both cell surface and soluble forms, though little is known of the regulation and functional significance of these forms. We show here that tissue-specific alternative splicing gives two...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Adhesion
- Cell Line
- Cells, Cultured
- Chromosome Deletion
- DNA Replication
- Growth Substances
- Mast Cells
- Mice
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- RNA Splicing