Article
Polymorphisms in nucleotide excision repair genes and DNA repair capacity phenotype in sisters discordant for breast cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2006
Shen Jing, Desai Manisha, Agrawal Meenakshi, Kennedy David O, Senie Ruby T, Santella Regina M, Terry Mary Beth
Abstract excerpt
Interindividual differences in DNA repair capacity (DRC) may play a critical role in breast cancer risk. Previously, we determined that DRC measured via removal of in vitro-induced benzo[a]pyrene diolepoxide-DNA adducts in lymphoblastoid cell lines was lower in cases compared with controls among sisters discordant for breast cancer from the Metropolitan New York Registry of Breast Cancer Families. We have now...
Topics
- Adult
- Breast Neoplasms
- DNA Repair
- Female
- Genotype
- Humans
- Middle Aged
- Phenotype
- Polymorphism, Single Nucleotide
- ROC Curve
- Siblings