Article
Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility.
The Journal of biological chemistry - 10 Nov 2006
Unoki Motoko, Shen Jiang Cheng, Zheng Zhi-Ming, Harris Curtis C
Abstract excerpt
The ING4 gene is a candidate tumor suppressor gene that functions in cell proliferation, contact inhibition, and angiogenesis. We identified three novel splice variants of ING4 with differing activities in controlling cell proliferation, cell spreading, and cell migration. ING4_v1 (the longest splice variant), originally identified as ING4, encodes an intact nuclear localization signal (NLS), whereas the other...
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