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Article

Nuclear localization of ING3 is required to suppress melanoma cell migration, invasion and angiogenesis.

Biochemical and biophysical research communications - 25 Jun 2020

Zhou Ruiyao, Rotte Anand, Li Gang, Chen Xiaolei, Chen Guangdi, Bhandaru Madhuri

Abstract excerpt

Inhibitor of growth family member 3 (ING3), a tumor suppressor, plays crucial roles in cell cycle regulation, apoptosis and transcription. Previous studies suggest important roles of nuclear ING3, however, the nuclear localization sequence (NLS) of ING3 is not defined and its biological functions remain to be elucidated. In this study, various ING3 mutants were generated to identify its NLS. The NLS of ING3 was...

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Identifiers

PMID: 32334834
DOI: 10.1016/j.bbrc.2020.04.056

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