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Article

Functional impact of cancer-associated mutations in the tumor suppressor protein ING4.

Carcinogenesis - 1 Nov 2010

Moreno Alberto, Palacios Alicia, Orgaz Jose Luis, Jimenez Benilde, Blanco Francisco J, Palmero Ignacio

Abstract excerpt

Inhibitor of growth 4 (ING4) is a member of the ING family of tumor suppressor proteins. In this study, we have analyzed the impact of two mutations in ING4 associated with human tumors (Y121N and N214D), testing their behavior in a series of functional, biochemical and structural analyses. We report that the N214D mutation dramatically dampened the ability of ING4 to inhibit proliferation, anchorage-independent...

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Source

Identifiers

PMID: 20705953
DOI: 10.1093/carcin/bgq171

Genes

ING4

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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