Article
Activation of ERK by altered RNA splicing in cancer
2022-09-02
Abstract excerpt
<h4>ABSTRACT</h4> Many cancers carry change-of-function mutations affecting RNA splicing factors, however, less is known about the functional consequences of upregulated RNA splicing factors in cancer. Here, we demonstrate that SMNDC1, a poorly studied splicing factor, which we found to be upregulated in multiple carcinomas and associated with poor patient prognosis, promotes cell proliferation, clonal expansion,...
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Identifiers and source
- Literature Corpus work
- 18bf5351-c8f8-5ab6-a2d2-dea2be6b0985
- DOI
- 10.1101/2022.08.31.505957