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Article

Allelic differences affecting invariant chain dependency of MHC class II subunit assembly.

Immunity - 1 Mar 1995

Bikoff E K, Germain R N, Robertson E J

Abstract excerpt

The conserved invariant chain associates with highly polymorphic alpha and beta subunits guiding class II transport through the secretory pathway. Early associations of these three polypeptides inside antigen-presenting cells are poorly understood. The present experiments provide a detailed picture of the structure and fate of class II alpha and beta subunits in invariant chain mutants possessing different MHC...

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Identifiers

PMID: 7697546
DOI: 10.1016/1074-7613(95)90054-3

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Allelic differences affecting invariant chain dependency of MHC class II subunit assembly.PMID 7697546Read ↗

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Allele-dependent association of chicken MHC class I molecules with the invariant chain.Semantic proximity Read ↗

Deletion of a C-terminal sequence of the class II-associated invariant chain abrogates invariant chains oligomer formation and class II antigen presentation.Semantic proximity Read ↗

Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-Invariant αβ TCRs Specific for a Conserved Peptide-Qa-1b MHC Class Ib Ligand.Semantic proximity Read ↗

Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.Semantic proximity Read ↗

An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading.Semantic proximity Read ↗

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Dissecting MHC class II export, B cell maturation, and DM stability defects in invariant chain mutant mice.Semantic proximity Read ↗

Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production.Semantic proximity Read ↗

Invariant chains with the class II binding site replaced by a sequence from influenza virus matrix protein constrain low-affinity sequences to MHC II presentation.Semantic proximity Read ↗

Invariant chain association with MHC class I: preference for HLA class I/beta 2-microglobulin heterodimers, specificity, and influence of the MHC peptide-binding groove.Semantic proximity Read ↗

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