Article
EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma.
International journal of cancer - 20 Feb 2003
Miyazaki Tatsuya, Kato Hiroyuki, Fukuchi Minoru, Nakajima Masanobu, Kuwano Hiroyuki
Abstract excerpt
EphA2 is a member of the Eph family of receptor tyrosine kinases, which interact with cell-bound ligands known as ephrins. EphA2 expression was investigated by immunohistochemistry with an anti-EphA2 monoclonal antibody in 80 patients with esophageal squamous cell carcinoma (ESCC) who had undergone surgery. EphA2 overexpression was positive in 40 of the 80 patients (50%). A significant correlation was observed...
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