Article
Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival.
BMC cancer - 1 Jun 2006
Herath Nirmitha I, Spanevello Mark D, Sabesan Sabe, Newton Tanya, Cummings Margaret, Duffy Shannon, Lincoln Douglas, Boyle Glen, Parsons Peter G, Boyd Andrew W
Abstract excerpt
BACKGROUND: Increased expression of Eph receptor tyrosine kinases and their ephrin ligands has been implicated in tumor progression in a number of malignancies. This report describes aberrant expression of these genes in ovarian cancer, the commonest cause of death amongst gynaecological malignancies. METHODS: Eph and ephrin expression was determined using quantitative real time RT-PCR. Correlation of gene...
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