Article
Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer.
Cancer letters - 30 Apr 2013
Nadkarni Niyati J, Geest Koen De, Neff Traci, Young Barry De, Bender David P, Ahmed Amina, Smith Brian J, Button Anna, Goodheart Michael J
Abstract excerpt
We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was elevated in tumors with p53 null mutations compared to p53 missense mutation or no mutation....
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