Article

Epstein-Barr virus reprograms human B-lymphocytes immediately in the pre-latent phase of infection

2018-12-31

Abstract excerpt

Epstein-Barr virus (EBV) is a human tumor virus and a model of herpesviral latency. The virus efficiently infects resting human B-lymphocytes and induces their continuous proliferation in vitro, which mimics certain aspects of EBV’s oncogenic potential in vivo. This seminal finding was made 50 years ago, but how EBV activates primary human B-lymphocytes and how lymphoblastoid cell lines (LCLs) evolve from the EBV-...

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Literature Corpus work: e9213cb7-171f-55d8-a33d-ca5792cddbdc
DOI: 10.1101/503268

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