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Article

Epstein–Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infection

24 Jul 2019

Abstract excerpt

Epstein-Barr virus (EBV) is a human tumor virus and a model of herpesviral latency. The virus efficiently infects resting human B lymphocytes and induces their continuous proliferation in vitro, which mimics certain aspects of EBV's oncogenic potential in vivo. How lymphoblastoid cell lines (LCLs) evolve from the infected lymphocytes is uncertain. We conducted a systematic time-resolved longitudinal study of...

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PMID: 31341086
DOI: 10.1073/pnas.1901314116

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