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Article

EBNA1 regulates cellular gene expression by binding cellular promoters

22 Dec 2009

Abstract excerpt

Epstein-Barr virus (EBV) is associated with several types of lymphomas and epithelial tumors including Burkitt's lymphoma (BL), HIV-associated lymphoma, posttransplant lymphoproliferative disorder, and nasopharyngeal carcinoma. EBV nuclear antigen 1 (EBNA1) is expressed in all EBV associated tumors and is required for latency and transformation. EBNA1 initiates latent viral replication in B cells, maintains the...

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PMID: 20080792
DOI: 10.1073/pnas.0911676106

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