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Article

Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells.

The Journal of biological chemistry - 1 Dec 2006

Chen Fei, Lu Yongju, Castranova Vince, Li Zhiwei, Karin Michael

Abstract excerpt

The IkappaB kinase complex (IKK) is central to the activation of NF-kappaB, a critical transcription factor governing expression of genes involved in cell proliferation and anti-apoptotic responses. Mice with genetic disruptions of the Ikkbeta or Ikkgamma gene loci die during embryogenesis because of severe hepatic apoptosis. We now show that Ikkbeta gene deficiency promotes migration and proliferation of mouse...

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Identifiers

PMID: 16966325
DOI: 10.1074/jbc.M603631200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells.PMID 16966325Read ↗

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