Article
Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressor.
Molecular cancer research : MCR - 1 Mar 2011
Kwak Youn-Tae, Radaideh Sofyan M, Ding Lianghao, Li Rui, Frenkel Eugene, Story Michael D, Girard Luc, Minna John, Verma Udit N
Abstract excerpt
The catalytic subunits of IκB kinase (IKK) complex, IKKα and IKKβ, are involved in activation of NF-κB and in mediating a variety of other biological functions. Though these proteins have a high-sequence homology, IKKα exhibits different functional characteristics as compared with IKKβ. Earlier, we have shown that cyclin D1 is overexpressed and predominantly localized in the nucleus of IKKα(-/-) cells, indicating...
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