Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IKK1-deficient mice exhibit abnormal development of skin and skeleton.

Genes & development - 15 May 1999

Li Q, Lu Q, Hwang J Y, Büscher D, Lee K F, Izpisua-Belmonte J C, Verma I M

Abstract excerpt

IkappaB kinases (IKKs) IKK1 and IKK2 are two putative IkappaBalpha kinases involved in NF-kappaB activation. To examine the in vivo functions of IKK1, we generated IKK1-deficient mice. The mutant mice are perinatally lethal and exhibit a wide range of developmental defects. Newborn mutant mice have shiny, taut, and sticky skin without whiskers. Histological analysis shows thicker epidermis, which is unable to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Embryo, Mammalian
Share to Epidermis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to I-kappa B Kinase

Share to Interleukin-1

Share to Interleukin-6

Share to NF-kappa B

Share to Skin Abnormalities

Source

Open in PubMed Open full text

Identifiers

PMID: 10346820
DOI: 10.1101/gad.13.10.1322
PMCID: PMC316728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IKK1-deficient mice exhibit abnormal development of skin and skeleton.PMID 10346820Read ↗

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.Semantic proximity Read ↗

Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation.Semantic proximity Read ↗

Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation.Semantic proximity Read ↗

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.Semantic proximity Read ↗

IKK-related genetic diseases: probing NF-κB functions in humans and other matters.Semantic proximity Read ↗

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2Semantic proximity Read ↗

IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.Semantic proximity Read ↗

Nuclear versus cytoplasmic IKKα signaling in keratinocytes leads to opposite skin phenotypes and inflammatory responses, and a different predisposition to cancer.Semantic proximity Read ↗

The NF-kappaB signaling pathway in human genetic diseases.Semantic proximity Read ↗

Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts.Semantic proximity Read ↗

The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms.Semantic proximity Read ↗

RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.