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Article

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.

Journal of cell science - 15 Mar 2008

Johansen Lars Dan, Naumanen Tiina, Knudsen Astrid, Westerlund Nina, Gromova Irina, Junttila Melissa, Nielsen Christina, Bøttzauw Trine, Tolkovsky Aviva, Westermarck Jukka, Coffey Eleanor T, Jäättelä Marja, Kallunki Tuula

Abstract excerpt

Loss-of-function mutations in the IKBKAP gene, which encodes IKAP (ELP1), cause familial dysautonomia (FD), with defective neuronal development and maintenance. Molecular mechanisms leading to FD are poorly understood. We demonstrate that various RNA-interference-based depletions of IKAP lead to defective adhesion and migration in several cell types, including rat primary neurons. The defects could be rescued by...

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Identifiers

PMID: 18303054
DOI: 10.1242/jcs.013722

Genes

ELP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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