Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The IkappaB kinase - a bridge between inflammation and cancer.

Cell research - 1 Mar 2008

Karin Michael

Abstract excerpt

A potential link between inflammation and cancer has been suspected for over a century, but the exact molecular mechanisms connecting the two remained nebulous. We proposed that NF-kappaB transcription factors regulated via the IkappaB kinase (IKK) complex play a critical role in coupling inflammation and cancer and have set out to test this hypothesis in mouse models of cancer. Using mice bearing mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to I-kappa B Kinase
Share to Inflammation
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasm Metastasis

Share to Neoplasms, Experimental

Share to NF-kappa B

Source

Identifiers

PMID: 18301380
DOI: 10.1038/cr.2008.30

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The IkappaB kinase - a bridge between inflammation and cancer.PMID 18301380Read ↗

Attribution of NF-κB Activity to CHUK/IKKα-Involved CarcinogenesisSemantic proximity Read ↗

NF-kappaB: Key mediator of inflammation-associated cancerSemantic proximity Read ↗

Molecular pathways in cancer-related inflammationSemantic proximity Read ↗

Advances in Targeting IKK and IKK-Related Kinases for Cancer TherapySemantic proximity Read ↗

The role of the transcription factor NF-kB in the pathogenesis of inflammation and carcinogenesis. Modulation capabilitiesSemantic proximity Read ↗

NF-κB in inflammation and cancerSemantic proximity Read ↗

IKKbeta leads to an inflammatory skin disease resembling interface dermatitis.Semantic proximity Read ↗

NF-κB inducing kinase: A key regulator in the immune system and in cancerSemantic proximity Read ↗

The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity.Semantic proximity Read ↗

IL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy ResistanceSemantic proximity Read ↗

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.Semantic proximity Read ↗

Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ InhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.