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Article

IKKbeta leads to an inflammatory skin disease resembling interface dermatitis.

The Journal of investigative dermatology - 1 Jun 2010

Page Angustias, Navarro Manuel, Garín Marina, Pérez Paloma, Casanova M Llanos, Moreno Rodolfo, Jorcano José L, Cascallana José L, Bravo Ana, Ramírez Angel

Abstract excerpt

IKKbeta is a subunit of the IkappaB kinase (IKK) complex required for NF-kappaB activation in response to pro-inflammatory signals. NF-kappaB regulates the expression of many genes involved in inflammation, immunity, and apoptosis, and also controls cell proliferation and differentiation in different tissues; however, its function in skin physiopathology remains controversial. In this study we report the...

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Identifiers

PMID: 20200541
DOI: 10.1038/jid.2010.28

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Related research

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IKKbeta leads to an inflammatory skin disease resembling interface dermatitis.PMID 20200541Read ↗

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Pathogenic Role of Cytoplasmic IKKα in Meibomian Gland Dysfunction and Dry Eye DiseaseSemantic proximity Read ↗

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.Semantic proximity Read ↗

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Cutting Edge: NF-κB p65 and c-Rel Control Epidermal Development and Immune Homeostasis in the SkinSemantic proximity Read ↗

IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin.Semantic proximity Read ↗

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