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Article

MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.

Molecular and cellular biology - 1 Jan 2005

Zhang Lin, Deng Maoxian, Parthasarathy Ranjani, Wang Lei, Mongan Maureen, Molkentin Jeffery D, Zheng Yi, Xia Ying

Abstract excerpt

Activins and other members of the transforming growth factor beta family play a critical role in morphological changes of the epidermis that require epithelial cell movement. We investigated the molecular pathways in the transmission of activin signals that lead to actin reorganization and epithelial cell migration. We found that activins cause the activation of RhoA but not of Rac and CDC42, leading to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15601830
DOI: 10.1128/MCB.25.1.60-65.2005
PMCID: PMC538759

Genes

CDC42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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