Article
Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction.
Neurobiology of disease - 1 Nov 2006
Dierssen Mara, Gratacòs Mònica, Sahún Ignasi, Martín Miguel, Gallego Xavier, Amador-Arjona Alejandro, Martínez de Lagrán María, Murtra Patricia, Martí Eulalia, Pujana Miguel A, Ferrer Isidre, Dalfó Esther, Martínez-Cué Carmen, Flórez Jesús, Torres-Peraza Jesús F, Alberch Jordi, Maldonado Rafael, Fillat Cristina, Estivill Xavier
Abstract excerpt
Accumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system. TgNTRK3 mice show increased anxiety-like behavior and enhancement of panic reaction in the mouse defense test battery, along with an increase in the number and density of...
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