Article

Evolutionary Perspectives on Anxiety: Telencephalic Circuitry and the Anxiogenic Role of TrkB Signaling in Tuberous Sclerosis Complex

2025-06-25

Abstract excerpt

Tuberous Sclerosis Complex (TSC) is a genetic disease which manifests as a range of neurological symptoms, including benign brain tumors, epilepsy, and TSC-associated neuropsychiatric disorders (TANDs). Among the latter, according to recent reports, anxiety and mood disorders affect over 50% of patients. We have previously demonstrated anxiety-like behavioral symptoms in the zebrafish model of TSC, which were resc...

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Literature Corpus work: d177cd5b-0c79-531a-a916-061bee699e0a
DOI: 10.1101/2025.06.23.661056

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