Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system

Abstract excerpt

The mammalian trkC gene encodes a tyrosine protein kinase that serves as a functional receptor for neurotrophin-3 (NT-3). Here, we report that trkC is widely expressed in the developing and adult nervous system. Using in situ hybridization, we first detect trkC transcripts in the telencephalon and spinal cord of embryonic day 9.5 mouse embryos. In later embryonic development, trkC is expressed in various...