Article
Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice.
Genes & development - 15 Jul 1998
Bilinski P, Roopenian D, Gossler A
Abstract excerpt
In eutherian mammals, implantation and establishment of the chorioallantoic placenta are essential for embryo development and survival. As a maternal response to implantation, uterine stromal cells proliferate, differentiate, and generate the decidua, which encapsulates the conceptus and forms the maternal part of the placenta. Little is known about decidual functions and the molecular interactions that regulate...
Topics
- Animals
- Decidua
- Embryonic and Fetal Development
- Female
- Gene Expression
- Gene Targeting
- Interleukin-11
- Interleukin-11 Receptor alpha Subunit
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutagenesis
- Phenotype
- Placentation
- Receptors, Interleukin
- Receptors, Interleukin-11
- Uterus