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Article

Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.

Diabetes - 1 Mar 2011

Gu Yanyun, Lindner Jill, Kumar Anil, Yuan Weiping, Magnuson Mark A

Abstract excerpt

OBJECTIVE: We examined the role of Rictor/mammalian target of rapamycin complex 2 (mTORC2), a key component of the phosphotidylinositol-3-kinase (PI3K)/mTORC2/AKT signaling pathway, in regulating both β-cell mass and function. RESEARCH DESIGN AND METHODS: Mice with β-cell-specific deletions of Rictor or Pten were studied to determine the effects of deleting either or both genes on β-cell mass and glucose...

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Source

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Identifiers

PMID: 21266327
DOI: 10.2337/db10-1194
PMCID: PMC3046843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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