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Article

The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms.

Journal of neurosurgery - 1 Sept 2006

Pannu Hariyadarshi, Kim Dong H, Guo Dongchuan, King Terri M, Van Ginhoven Grace, Chin Toinette, Chang Katherine, Qi Yuhua, Shete Sanjay, Milewicz Dianna M

Abstract excerpt

OBJECT: Matrix metalloproteinases (MMPs) are a family of endopeptidases that mediate vascular remodeling by degrading extracellular matrix components, such as collagen and elastin. On the basis of accumulating evidence that implicates increased MMP-2 (gelatinase A) and MMP-9 (gelatinase B) amounts and activity in the pathogenesis of aneurysms, the authors investigated the genetic association between polymorphisms...

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Source

Identifiers

PMID: 16961137
DOI: 10.3171/jns.2006.105.3.418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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