Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis.

doi:10.1080/02688697.2018.1427213

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Article

Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis.

British journal of neurosurgery - 1 Jun 2018

Alg Varinder S, Ke Xiayi, Grieve Joan, Bonner Stephen, Walsh Daniel C, Bulters Diederik, Kitchen Neil, Houlden Henry, Werring David J

Abstract excerpt

INTRODUCTION: Abnormalities in Matrix Metalloproteinase (MMP) genes, which are important in extracellular matrix (ECM) maintenance and therefore arterial wall integrity are a plausible underlying mechanism of intracranial aneurysm (IA) formation, growth and subsequent rupture. We investigated whether the rs243865 C > T SNP (single nucleotide polymorphism) within the MMP-2 gene (which influences gene...

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PMID: 29334797
DOI: 10.1080/02688697.2018.1427213

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