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Article

Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway.

The Journal of investigative dermatology - 1 Feb 2007

Gaggioli Cédric, Robert Guillaume, Bertolotto Corine, Bailet Olivier, Abbe Patricia, Spadafora Anne, Bahadoran Philippe, Ortonne Jean-Paul, Baron Véronique, Ballotti Robert, Tartare-Deckert Sophie

Abstract excerpt

Melanomas are malignant tumors of melanocytes that, if not detected early, are highly aggressive and poorly treatable. Activation of extracellular signal-regulated (ERK)/mitogen-activated protein (MAP) kinase signaling is commonly found in melanomas mainly through oncogenic mutations of B-Raf. We previously reported that activation of ERK/MAP kinase stimulates synthesis of fibronectin by upregulating the...

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PMID: 16960555
DOI: 10.1038/sj.jid.5700524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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