Article
Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions.
Oncogene - 11 Apr 2013
Couts K L, Anderson E M, Gross M M, Sullivan K, Ahn N G
Abstract excerpt
Over two-thirds of melanomas have activating mutations in B-Raf, leading to constitutive activation of the B-Raf/MKK/ERK signaling pathway. The most prevalent mutation, B-RafV600E, promotes cancer cell behavior through mechanisms that are still incompletely defined. Here, we used a sensitive microarray profiling platform to compare microRNA (miRNA) expression levels between primary melanocytes and...
Topics
- Cell Proliferation
- Gene Expression Regulation, Neoplastic
- Humans
- MAP Kinase Kinase 1
- MAP Kinase Kinase 2
- MAP Kinase Signaling System
- Melanocytes
- Melanoma
- MicroRNAs
- Mutation
- Neoplasm Invasiveness
- Oligonucleotide Array Sequence Analysis
- Proto-Oncogene Proteins B-raf
- RNA Interference