Article
Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions.
Oncogene - 11 Apr 2013
Couts K L, Anderson E M, Gross M M, Sullivan K, Ahn N G
Abstract excerpt
Over two-thirds of melanomas have activating mutations in B-Raf, leading to constitutive activation of the B-Raf/MKK/ERK signaling pathway. The most prevalent mutation, B-RafV600E, promotes cancer cell behavior through mechanisms that are still incompletely defined. Here, we used a sensitive microarray profiling platform to compare microRNA (miRNA) expression levels between primary melanocytes and...
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