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Article

Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation.

Cancer research - 15 Feb 2003

Satyamoorthy Kapaettu, Li Gang, Gerrero Michelle R, Brose Marcia S, Volpe Patricia, Weber Barbara L, Van Belle Patricia, Elder David E, Herlyn Meenhard

Abstract excerpt

Dysregulated activation of Ras or its downstream effectors such as mitogen-activated protein kinase kinase and ERK has been shown to play a critical role in tumorigenesis of many cancer types. However, in melanoma, activating mutations in Ras are rarely observed and are limited to N-Ras in UV-exposed cells. In this study, we identify constitutively activated ERK in almost all melanoma cell lines and in tumor...

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Source

Identifiers

PMID: 12591721

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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