Article
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma.
Cancer research - 15 Feb 2007
Shields Janiel M, Thomas Nancy E, Cregger Melissa, Berger Aaron J, Leslie Michael, Torrice Chad, Hao Honglin, Penland Shannon, Arbiser Jack, Scott Glynis, Zhou Tong, Bar-Eli Menashe, Bear James E, Der Channing J, Kaufmann William K, Rimm David L, Sharpless Norman E
Abstract excerpt
The majority of human melanomas harbor activating mutations of either N-RAS or its downstream effector B-RAF, which cause activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase and the ERK MAPK cascade. The melanoma-relevant effectors of ERK activation, however, are largely unknown. In this work, we show that increased ERK activation correlates strongly with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.