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Article

Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells.

The Journal of biological chemistry - 5 Sept 2003

Conner Sean R, Scott Glynis, Aplin Andrew E

Abstract excerpt

Normal cells are dependent upon integrin-mediated adhesion to the extracellular matrix for cell proliferation and survival. Integrins regulate these processes partially through control of extracellular signal-regulated kinases 1 and 2 (ERK1/2). A trait of malignant cells is their ability to undergo anchorage-independent growth. Melanomas are tumors arising from normal melanocytes that, if undetected at an early...

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Source

Identifiers

PMID: 12821662
DOI: 10.1074/jbc.M305797200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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