Article
An antigen produced by splicing of noncontiguous peptides in the reverse order.
Science (New York, N.Y.) - 8 Sept 2006
Warren Edus H, Vigneron Nathalie J, Gavin Marc A, Coulie Pierre G, Stroobant Vincent, Dalet Alexandre, Tykodi Scott S, Xuereb Suzanne M, Mito Jeffrey K, Riddell Stanley R, Van den Eynde Benoît J
Abstract excerpt
CD8-positive T lymphocytes recognize peptides that are usually derived from the degradation of cellular proteins and are presented by class I molecules of the major histocompatibility complex. Here we describe a human minor histocompatibility antigen created by a polymorphism in the SP110 nuclear phosphoprotein gene. The antigenic peptide comprises two noncontiguous SP110 peptide segments spliced together in...
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