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Elucidation of the Signatures of Proteasome-Catalyzed Peptide Splicing

24 Sept 2020

Abstract excerpt

Proteasomes catalyze the degradation of endogenous proteins into oligopeptides, but can concurrently create spliced oligopeptides through ligation of previously non-contiguous peptide fragments. Recent studies have uncovered a formerly unappreciated role for proteasome-catalyzed peptide splicing (PCPS) in the generation of non-genomically templated human leukocyte antigen class I (HLA-I)-bound cis-spliced...

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PMID: 33072102
DOI: 10.3389/fimmu.2020.563800

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