Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Revelation of a cryptic major histocompatibility complex class II-restricted tumor epitope in a novel RNA-processing enzyme.

Cancer research - 1 Oct 2002

Topalian Suzanne L, Gonzales Monica I, Ward Yvona, Wang Xiang, Wang Rong-Fu

Abstract excerpt

CD4+ T-cell responses against human tumor antigens are a potentially critical component of the antitumor immune response. Molecular methods have been devised for rapidly identifying MHC class II-restricted tumor antigens and elucidating the recognized epitopes. We describe here the identification of neo-poly(A) polymerase (neo-PAP), a novel RNA processing enzyme overexpressed in a variety of human cancers, by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to Gene Library

Share to HLA-DR7 Antigen

Share to Polynucleotide Adenylyltransferase

Share to RNA, Neoplasm

Share to Subcellular Fractions

Source

Identifiers

PMID: 12359760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Revelation of a cryptic major histocompatibility complex class II-restricted tumor epitope in a novel RNA-processing enzyme.PMID 12359760Read ↗

RNA Transcription and Splicing Errors as a Source of Cancer Frameshift Neoantigens for VaccinesSemantic proximity Read ↗

Pervasive Intronic Polyadenylation Serves as a Potential Source of Cancer NeoantigensSemantic proximity Read ↗

Identification of the Cryptic HLA-I ImmunopeptidomeSemantic proximity Read ↗

Employing RNA editing to engineer personalized tumor-specific neoantigens (editopes)Semantic proximity Read ↗

Molecular mechanisms of non-genetic aberrant peptide production in cancer.Semantic proximity Read ↗

The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinomaSemantic proximity Read ↗

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer.Semantic proximity Read ↗

In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo.Semantic proximity Read ↗

RNA editing derived epitopes function as cancer antigens to elicit immune responsesSemantic proximity Read ↗

Spliced peptides and cytokine driven changes in the immunopeptidome of melanomaSemantic proximity Read ↗

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.Semantic proximity Read ↗

Identification of a naturally processed HLA-DR-restricted T-helper epitope in Epstein-Barr virus nuclear antigen type 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.