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Article

Using Genomic Data to Find Disease-Modifying Loci in Huntington's Disease (HD).

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Holmans Peter, Stone Tim

Abstract excerpt

In this chapter, genetic modifiers are defined, and the rationale for investigating them in HD explained. Issues involved in modeling the phenotype are discussed, using age at motor onset as an example. The statistical methods for analyzing genetic data (linkage and association) are discussed, along with the advantages and disadvantages of each. In particular, the advantage of a genome-wide approach over one...

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Identifiers

PMID: 29856030
DOI: 10.1007/978-1-4939-7825-0_20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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